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KMID : 0857020110260020179
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Kosin Medical Journal
2011 Volume.26 No. 2 p.179 ~ p.182
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A Case of Prolonged QT Interval Association with Galantamine
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Park Ju-Cheol
Kim Byung-Seok
Park Seong-Min
Park Il-Woo
Hong Young-Mi
Jeong Joon-Hoon
Cha Tae-Joon
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Abstract
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Among the Acetylcholinesterase inhibitors as used for Alzheimer’s disease treatment, Galantamine has been recently developed and widely used owing to proven its clinical efficacy and safety. However, it has reported that prolonged QT interval, which can lead to ventricular arrythimias such as Torsade de points, has developed in Galantamine-treated patients. A 74-year-old female Alzheimer’s patient been treated with galantamine for 8 months visited the hospital complaining about frequent dizziness. ECG monitor was performed promptly, it was informed that the prolonged QTc interval was increased 450 ms to 486 ms. So, we made her stop taking the galantamine, and after that QTc interval has normalized to 406 ms. In this article, we reported the first case on prolonged QT interval associated with galantamine in Korea.
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KEYWORD
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EKG, Galantamine, Prolonged QT interval
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